Anti-CD40 Polyclonal Antibody
品牌：solarbio | 货号：K001603P
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K001603P-50ul
solarbio
50ul
960.00元
K001603P-100ul
solarbio
100ul
1600.00元

英文名称
Anti-CD40 Polyclonal Antibody
别名
Bp50;CDW40;TNFRSF5;p50
应用
WB IF
稀释比例
WB 1:500-2000. IF 1:50-200.
交叉反应
Human Mouse Rat
蛋白分子量
31kDa
Gene ID
958
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, 
pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
Recombinant Protein of human CD40
性状
液体
Public 
Immunogen 
Range
Recombinant Protein of human CD40
Subcellular 
Locations
Cell membrane Secreted Single-pass type I membrane 
protein
Swiss Prot
P25942
克隆类型
Polyclonal Antibody
背景资料
This gene is a member of the TNF-receptor superfamily. 
The encoded protein is a receptor on antigen-
presenting cells of the immune system and is essential 
for mediating a broad variety of immune and 
inflammatory responses including T cell-dependent 
immunoglobulin class switching, memory B cell 
development, and germinal center formation. AT-hook 
transcription factor AKNA is reported to coordinately 
regulate the expression of this receptor and its ligand, 
which may be important for homotypic cell 
interactions. Adaptor protein TNFR2 interacts with this 
receptor and serves as a mediator of the signal 
transduction. The interaction of this receptor and its 
ligand is found to be necessary for amyloid-beta-
induced microglial activation, and thus is thought to be 
an early event in Alzheimer disease pathogenesis. 
Mutations affecting this gene are the cause of 
autosomal recessive hyper-IgM immunodeficiency type 
3 (HIGM3). Multiple alternatively spliced transcript 
variants of this gene encoding distinct isoforms have 
been reported.