Anti-ATF6 Polyclonal Antibody

品牌：solarbio | 货号：K001590P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001590P-50ul	solarbio	50ul	960.00元
K001590P-100ul	solarbio	100ul	1600.00元

英文名称 Anti-ATF6 Polyclonal Antibody
别名 ACHM7;ATF6A
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量 75kDa
Gene ID 22926
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ATF6
性状 液体
Public Immunogen Range Recombinant protein of human ATF6
Subcellular Locations Endoplasmic reticulum membrane Nucleus Single-pass type II membrane protein
Swiss Prot P18850
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

英文名称	Anti-ATF6 Polyclonal Antibody
别名	ACHM7;ATF6A
应用	WB
稀释比例	WB 1:500-2000.
交叉反应	Human Mouse Rat
蛋白分子量	75kDa
Gene ID	22926
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human ATF6
性状	液体
Public Immunogen Range	Recombinant protein of human ATF6
Subcellular Locations	Endoplasmic reticulum membrane Nucleus Single-pass type II membrane protein
Swiss Prot	P18850
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.